After Rouge went off to inspect the Wily Egg, she was captured and turned into Rouge Woman. Rouge Woman was then sent to stop Sonic the Hedgehog, Mega Man and their friends with the time-cloned Robot Masters. She proceeded to battle Knuckles before being de-roboticized by Mega Man and Rush.
- On the bottom of her feet are hearts unlike most of the Roboticized Masters who have circles on their feet. This could be because Rouge's actual design has hearts on her clothes.
- Rouge Woman is one the three female Roboticized Masters, the others being Rose Woman and Blaze Woman.
- In the Concept artwork, Rouge Woman's eyes are red, while in the comic they're green.
- Rouge Woman fighting Knuckles is probably a nod to their rivalry in the games.