Mutant Wrestling is a two-dimensional multiplayer loosely based on professional wrestling games, but more closely resembles a beat-'em up video game. Here, two players each takes control of a mutant version of a colorful anthropomorphic animal in a wrestling outfit (two playable characters have been revealed so far). The objective of the game is to defeat the opposing player in combat. The last player left standing is the winner.
The matches take place in a standard wrestling ring. Players can fight using combos and combo breakers (the execution of the latter causes the in-game announcer to shout "C-C-C-COMBO BREAKER"). Each time a successful attack is performed on a player, their respective health meter on the top of the screen depletes. Once a player's health is completely depleted, they will be defeated and a victory animation for the winner is played.
- The in-game announcer for Mutant Wrestling shouting "C-C-C-COMBO BREAKER" is a reference to the Killer Instinct franchise owned by Microsoft.
- A slightly altered version of the Pac-Man theme is used as the background music for Mutant Wrestling.