- The ROAD TO #50 starts here! Enjoy a TEN-ISSUE long adventure leading up to the EPIC SHOWDOWN in milestone issue #50.
- ROAD TRIP!!! The girls; Amy, Jewel, Tangle, and Belle, are heading off on a well-deserved camping trip. Between Dr. Eggman, Dr. Starline, and the Deadly Six, life has been a bit stressful, so they hope rest and relaxation will bring them some peace. Unfortunately... tensions are high and Amy's fortune card readings leave everyone feeling confused. Can the girls extinguish the awkwardness before it burns out of control? Find out in "TRIAL BY FIRE," part one by Evan Stanley.
Trial by Fire, Part 1
- This issue was originally scheduled for release on 22 September 2021, but was delayed to 6 October 2021, and later again to 13 October 2021.
- SONIC THE HEDGEHOG #45 CVR A STANLEY. Previews World (25 June 2021). Retrieved on 25 June 2021.
- SONIC THE HEDGEHOG #45 CVR B SKELLY. Previews World (25 June 2021). Retrieved on 25 June 2021.
- SONIC THE HEDGEHOG #45 CVR C 10 COPY INCV FOURDRAINE (. Previews World (25 June 2021). Retrieved on 25 June 2021.