The Genesis Unit is a group of Robot Masters made by Dr. Wily in the year 20XX in the Mega Man comic series published by Archie Comics. In the Sonic the Hedgehog and Mega Man comic crossover event, Sonic & Mega Man: Worlds Collide, following the release of the Genesis Wave, the group was revived by Dr. Wily and Dr. Eggman.
At some point in the rewritten reality of the Earth in the year 20XX, created due to the Genesis Wave, the Genesis Unit was utterly destroyed by Mega Man. However, by using the time-space altering properties of the Genesis Wave, Dr. Eggman and Dr. Wily were able to revive the Genesis Unit. (WC #1, #5)
At Skull Egg Zone, Sonic the Hedgehog, Mega Man, Proto Man, Miles "Tails" Prower, and Mega Man's robotic dog, Rush, found themselves facing Copy Robot. Sonic, noticing the same robot that aimed at Silver earlier at Green Hill Zone. The two brace on to attack Copy Robot, but the Genesis Unit strikes behind Copy Robot. As Sonic faces Buster Rod G (and insults the robot by calling him Kiki), Mega Man faces Copy Robot, and Tails and Proto Man face Hyper Storm H and Mega Water S, respectfully. After several times of being hit, Mega Man uses his Tails Wind Master Weapon he got from a roboticized Tails back at Mega City to blow away Copy Robot. Mega Man uses this Master Weapon against Hyper Storm H and then Buster Rod G, with a distraction provided by Sonic, knocking both of them down. Mega Water S, realizing he's outnumbered runs away but he is shot by Proto Man. (WC #5)
However, the trio were later recreated again as part of a massive army of Robot Masters led by Rouge Woman against the heroes and their assembled allies. After battling the heroes briefly, they and the rest of their fellow Robot Masters were caught up in the effects of the Super Genesis Wave, which rewrote all of reality, but then had their world restored to its former condition by Super Mega Man. (WC #9, WC #12)
- The Genesis Unit is named so, in reference to the fact that their three members first debuted in Mega Man: The Wily Wars, a game released exclusively for the Sega Genesis (it is also the only Mega Man game released for the system). Fittingly, they're depicted on the cover facing Sonic: the mascot of Sega who also made his debut on the same console.
- All of the members of the Genesis Unit are based off of characters from the Journey to the West Chinese novels. In fact, Sonic, when facing Buster Rod G, said that this looks familiar, as he was referencing to Monkey Khan, a character also based from the Journey to the West novel.