E-105 Zeta may refer to:
Characters
- E-105 Zeta, the character in the Sonic the Hedgehog video games.
- E-105 Zeta (Archie), the character in the Sonic the Hedgehog comic series and its spin-offs published by Archie Comics.
- E-105 Zeta (Pre-Super Genesis Wave), the version of E-102 Gamma before the Super Genesis Wave.
- E-105 Zeta (Sonic X), the character in the anime series Sonic X.