E-104 Epsilon may refer to:
- E-104 Epsilon, the character in the Sonic the Hedgehog video games.
- E-104 Epsilon (Archie), the character in the Sonic the Hedgehog comic series and its spin-offs published by Archie Comics.
- E-104 Epsilon (Sonic X), the character in the anime series Sonic X.
Community content is available under CC-BY-SA unless otherwise noted.