Cream's early history was most likely largely the same as her Mobius Prime counterpart's. The point of divergence was when Knuckles became corrupted by his chaos powers and decided to conquer Mobius. Cream eventually joined the countless heroes and villains alike that fell to Knuckles, now having assumed the mantle of Enerjak, and had her Core removed.
During Enerjak’s final battle against Silver the Hedgehog, Cream's Prelate was summoned among a horde in order to overwhelm the young time-traveler, but to no avail.
This version of Cream is notable in being the first version of Cream in any media to be seen without some version of Cheese as a companion.