The Chemical Plant Zone is an outlined cityarea located in a gray and barren expanse. The place consists mainly of red, blue and gray buildings and is highly industrialized, featuring giant pipelines that wind through the Zone, smokestacks, and all kinds of warning signs about toxics and advertisements for gasoline stations.
Instead of roads, the Chemical Plant Zone has giant pipelines which travelers must use as paths by driving on top of them. On the ground are also several cracks-filled pools with green-yellow toxics that can dissolve an entire racing car in little over eleven seconds.
Having entered the Mobius 5000 against Dr. Robotnik's Race Bots, Sonic, Tails and Professor Caninestein entered the Chemical Plant Zone after passing the race's halfway point, where they took the lead over Ex-Moto and Speedo. There, Scratch and Grounder tried to sabotage Sonic's race car when he went in for the only pit stop for 100 miles by replacing its engine with a time bomb. However, Scratch mistook Grounder for the bomb and place him as the engine in the race car. After Sonic and his team then drove away to rejoin the race, the bomb detonated shortly after, destroying the pit stop and injuring Scratch.
Back in the race, Sonic's team and Speedo were neck-at-neck on the Chemical Plant Zone's paths until Speedo knocked the heroes into a pool of toxic chemicals with sharp tire spikes. Before the toxicants could dissolve the car though, Sonic spun them out of the pool and back into the race while slicing Speedo in half. Robotnik then ordered Ex-Moto to focus on winning the race, and Sonic's team and Ex-Moto raced each other out of the Chemical Zone and into the Casino Zone.
- The location is based of the Zone of the same name from the Sega Mega Drive video game Sonic the Hedgehog 2.