Auntie Bodies are the embodiments of the Freedom Fighters' natural immune systems. Each Freedom Fighter has their own Auntie Bodies, which looks like an elderly female version of the Freedom Fighter.
When Dr. Robotnik infected the Freedom Fighters except Sonic with the robotic germ known as the French Frirus, Rotor shrunk Sonic to microscopic size so that he could enter Rotor's body to defeat the robotic illness. When Sonic found Rotor's Auntie Bodies, she informs him that she and her counterparts within the other Freedom Fighters have given up battling the French Frius.
Sonic set off alone to battle the French Frirus, represented inside Rotor's body by the French Foreign Lesions, Paris-Site, and Fever. Sonic defeated the Lesions, but was nearly overwhelmed by Fever. However, before Paris-Site could deliver the final blow with his "Microbe Bar", Rotor's Auntie Bodies took the Microbe Bar and fought back, knocking out Paris-Site and giving Sonic a chance to break the Fever. Rotor's Auntie Bodies then called the Auntie Bodies of the other Freedom Fighters on her one-celled cellular phone, telling them how to beat the French Frirus. The Freedom Fighters soon recovered.
- The name Auntie Bodies is used as both a singular and a plural.
- The name Auntie Bodies is a reference to the word auntie (a familiar term for an aunt) and antibodies.