User blog comment:SalaComMander/Knuckles Broke the Fourth Wall/@comment-1218831-20100911043202/@comment-1535286-20100913174853

Yes, they do it a lot in Metal Gear. Snake even broke the fourth wall a few times in Brawl.

Most notably, the scene where Snake's box is seen. Several levels later, he jumps out of the box and says "Kept ya waiting, huh?"